Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

G. Dobson; N. Klein; P. Veys; W. Qasim; J. Silva; I.L. Cheng; D. Shingadia; G. Tudor-Williams; S.A. Watters; H. Lyall; A. Rao; C. Foster; A. Bamford

Journal of Virus Eradication (Jul 2019)

Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

G. Dobson,
N. Klein,
P. Veys,
W. Qasim,
J. Silva,
I.L. Cheng,
D. Shingadia,
G. Tudor-Williams,
S.A. Watters,
H. Lyall,
A. Rao,
C. Foster,
A. Bamford

Affiliations

G. Dobson: Paediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
N. Klein: Paediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK
P. Veys: UCL Great Ormond Street Institute of Child Health, London, UK; Paediatric Bone Marrow Transplant Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK
W. Qasim: UCL Great Ormond Street Institute of Child Health, London, UK; Paediatric Immunology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK
J. Silva: Paediatric Bone Marrow Transplant Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK
I.L. Cheng: Paediatric Pharmacy Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK
D. Shingadia: Paediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK
G. Tudor-Williams: Paediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UK; Division of Infectious Diseases, Imperial College London, London, UK
S.A. Watters: UCL Great Ormond Street Institute of Child Health, London, UK
H. Lyall: Paediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UK
A. Rao: Paediatric Haematology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK
C. Foster: Paediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UK
A. Bamford: Paediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK; Corresponding author: Alasdair Bamford Paediatric Infectious Diseases Department, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK

Journal volume & issue: Vol. 5, no. 3
pp. 174 – 177

Abstract

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This report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the lower limit of detection throughout and following transplant and is currently <20 RNA copies/mL. The child is currently in remission from JMML, but HIV DNA remains detectable despite myeloablative conditioning and sustained plasma HIV viral suppression.

Published in Journal of Virus Eradication

ISSN: 2055-6640 (Print); 2055-6659 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Microbiology; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/journal-of-virus-eradication

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