Nature Communications (Feb 2023)

Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

  • Maximilian Wranik,
  • Tobias Weinert,
  • Chavdar Slavov,
  • Tiziana Masini,
  • Antonia Furrer,
  • Natacha Gaillard,
  • Dario Gioia,
  • Marco Ferrarotti,
  • Daniel James,
  • Hannah Glover,
  • Melissa Carrillo,
  • Demet Kekilli,
  • Robin Stipp,
  • Petr Skopintsev,
  • Steffen Brünle,
  • Tobias Mühlethaler,
  • John Beale,
  • Dardan Gashi,
  • Karol Nass,
  • Dmitry Ozerov,
  • Philip J. M. Johnson,
  • Claudio Cirelli,
  • Camila Bacellar,
  • Markus Braun,
  • Meitian Wang,
  • Florian Dworkowski,
  • Chris Milne,
  • Andrea Cavalli,
  • Josef Wachtveitl,
  • Michel O. Steinmetz,
  • Jörg Standfuss

DOI
https://doi.org/10.1038/s41467-023-36481-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitude in time.