Pharmaceutical Technology in Hospital Pharmacy (Sep 2021)
Vial coring and fragmentation incidence after angled penetration of rubber stoppers with single-use hypodermic needles
Abstract
Particles due to fragmentation present a clear risk to the patient. Reported fragmentation rates vary, and an insertion angle at 45°, as opposed to 90°, has been proposed as a mitigation strategy. So, this study evaluated the fragmentation rates induced by single-use hypodermic needles using different angled penetration techniques.
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