BRCA1-BARD1: the importance of being in shape

Abstract

The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation. We recently discovered that fork protection requires a conformational change of BRCA1 unimportant to homologous recombination repair, indicating separate roles for BRCA1 in these pathways.

Keywords

• brca1
• bard1
• pin1
• fork protection
• isomerization
• rad51