Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2

Yoshifumi Takahata; Hiromasa Hagino; Ayaka Kimura; Mitsuki Urushizaki; Sachi Kobayashi; Kanta Wakamori; Chika Fujiwara; Eriko Nakamura; Kayon Yu; Hiroshi Kiyonari; Kana Bando; Tomohiko Murakami; Toshihisa Komori; Kenji Hata; Riko Nishimura

doi:10.1038/s42003-021-02717-7

Communications Biology (Oct 2021)

Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2

Yoshifumi Takahata,
Hiromasa Hagino,
Ayaka Kimura,
Mitsuki Urushizaki,
Sachi Kobayashi,
Kanta Wakamori,
Chika Fujiwara,
Eriko Nakamura,
Kayon Yu,
Hiroshi Kiyonari,
Kana Bando,
Tomohiko Murakami,
Toshihisa Komori,
Kenji Hata,
Riko Nishimura

Affiliations

Yoshifumi Takahata: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Hiromasa Hagino: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Ayaka Kimura: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Mitsuki Urushizaki: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Sachi Kobayashi: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Kanta Wakamori: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Chika Fujiwara: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Eriko Nakamura: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Kayon Yu: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Hiroshi Kiyonari: Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
Kana Bando: Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research
Tomohiko Murakami: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Toshihisa Komori: Basic and Translational Research Center for Hard Tissue Disease, Nagasaki University Graduate School of Biomedical Sciences
Kenji Hata: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
Riko Nishimura: Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry

DOI: https://doi.org/10.1038/s42003-021-02717-7
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Takahata et al. investigate the functional role of SMOC1/2 proteins in skeletal development. They reveal a genetic pathway that includes Bmp2 and Runx2 inducing expression of the paralogous Smoc genes, which may offer novel and effective therapeutic strategies associated with various bone and cartilage diseases.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal