Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from <i>Nervilia concolor</i>
Thi-Ngoc-Mai Tran,
Guillaume Bernadat,
Dinh-Tri Mai,
Van-Kieu Nguyen,
Jirapast Sichaem,
Tan-Phat Nguyen,
Cong-Luan Tran,
Phuong-Vy Do,
Nguyen-Minh-An Tran,
Huu-Hung Nguyen,
Mehdi A. Beniddir,
Thuc-Huy Duong,
Pierre Le Pogam
Affiliations
Thi-Ngoc-Mai Tran
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100803, Vietnam
Guillaume Bernadat
Équipe “Pharmacognosie–Chimie des Substances Naturelles”, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France
Dinh-Tri Mai
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100803, Vietnam
Van-Kieu Nguyen
Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
Jirapast Sichaem
Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, Thailand
Tan-Phat Nguyen
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100803, Vietnam
Cong-Luan Tran
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100803, Vietnam
Phuong-Vy Do
Ho Chi Minh City University of Technology (HCMUT), Ho Chi Minh City 758307, Vietnam
Nguyen-Minh-An Tran
Industrial University of Ho Chi Minh City, Ho Chi Minh City 758307, Vietnam
Huu-Hung Nguyen
Faculty of Biotechnology, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh Str., Dist. 4, Ho Chi Minh City 758307, Vietnam
Mehdi A. Beniddir
Équipe “Pharmacognosie–Chimie des Substances Naturelles”, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France
Thuc-Huy Duong
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam
Pierre Le Pogam
Équipe “Pharmacognosie–Chimie des Substances Naturelles”, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France
Two new cycloartane glycosides, nervisides I−J, were isolated from Nervilia concolor whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the R configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score. These compounds were tested for cytotoxicity against K562 and MCF-7 tumor cell lines, revealing mild cytotoxic activity.
