Causative Agents, Antibiotic Resistance Patterns and Risk Factors in Early and Late Onset Neonatal Sepsis in a Neonatal Intensive Care Unit

Abstract

Introduction: Neonatal sepsis is one of the major causes of neonatal mortality. Causative agents, antibiotic resistance patterns and risk factors of sepsis differ from one region to another in the world. Periodic assessments of these will guide to use an appropriate antibiotics for rational empirical treatment and contribute to management of sepsis. Aim: To determine causative agents, antibiotic resistance patterns and risk factors of early and late onset neonatal sepsis. Materials and Methods: A total of 230 neonates diagnosed as sepsis were included in this retrospective study. Data collection was made by reviewing records of patients from laboratory and hospital information system of Konya Dr Ali Kemal Belviranlı Gynaecology, Obstetrics and Children Hospital between September 2015-May 2017. Blood samples were incubated in automated blood culture system. Subcultures were performed on 5% sheep blood agar and eosin methylene blue agar. Identification of microorganisms was firstly made by conventional methods. Further identification and antibiotic susceptibility tests were performed by automatic analyser. Results were considered statistically significant at p0.05). Conclusion: There were some differences and also similarities between aetiologic agents and antibiotic resistance patterns among data obtained in this study and those from other countries. This study contributed to epidemiological information and routine antibiotic surveillance to use appropriate antibiotics for empirical treatment of sepsis and prevent its complications.

Keywords

• aetiology
• bacterial profile
• blood cultures
• empirical treatment