Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Raquel Gomez-Sintes; Qisheng Xin; Juan Ignacio Jimenez-Loygorri; Mericka McCabe; Antonio Diaz; Thomas P. Garner; Xiomaris M. Cotto-Rios; Yang Wu; Shuxian Dong; Cara A. Reynolds; Bindi Patel; Pedro de la Villa; Fernando Macian; Patricia Boya; Evripidis Gavathiotis; Ana Maria Cuervo

doi:10.1038/s41467-022-31869-1

Nature Communications (Jul 2022)

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

Raquel Gomez-Sintes,
Qisheng Xin,
Juan Ignacio Jimenez-Loygorri,
Mericka McCabe,
Antonio Diaz,
Thomas P. Garner,
Xiomaris M. Cotto-Rios,
Yang Wu,
Shuxian Dong,
Cara A. Reynolds,
Bindi Patel,
Pedro de la Villa,
Fernando Macian,
Patricia Boya,
Evripidis Gavathiotis,
Ana Maria Cuervo

Affiliations

Raquel Gomez-Sintes: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Qisheng Xin: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Juan Ignacio Jimenez-Loygorri: Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas, CSIC
Mericka McCabe: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Antonio Diaz: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Thomas P. Garner: Department of Biochemistry, Albert Einstein College of Medicine
Xiomaris M. Cotto-Rios: Department of Biochemistry, Albert Einstein College of Medicine
Yang Wu: Department of Biochemistry, Albert Einstein College of Medicine
Shuxian Dong: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Cara A. Reynolds: Department of Pathology, Albert Einstein College of Medicine
Bindi Patel: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
Pedro de la Villa: Department; of System Biology, Universidad de Alcalá, Madrid, Spain and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)
Fernando Macian: Institute for Aging Studies of the Department of Medicine of the Albert Einstein College of Medicine
Patricia Boya: Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas, CSIC
Evripidis Gavathiotis: Institute for Aging Studies of the Department of Medicine of the Albert Einstein College of Medicine
Ana Maria Cuervo: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine

DOI: https://doi.org/10.1038/s41467-022-31869-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Gomez-Sintes et al. have developed small molecules that selectively activate chaperone-mediated autophagy by stabilizing the interaction between retinoic acid receptor alpha and its co-repressor N-CoR1. They demonstrate the protective effect of boosting chaperone-mediated autophagy against retinal degeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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