Nature Communications (Nov 2022)

Long-range GABAergic projections contribute to cortical feedback control of sensory processing

  • Camille Mazo,
  • Antoine Nissant,
  • Soham Saha,
  • Enzo Peroni,
  • Pierre-Marie Lledo,
  • Gabriel Lepousez

DOI
https://doi.org/10.1038/s41467-022-34513-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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Classically, corticofugal feedback projections that adjust sensory processing are excitatory. Here, the authors uncover the presence of top-down inhibitory projections from cortical GABAergic neurons in the olfactory system, which directly inhibit olfactory bulb circuits.