Novel double beta-lactam therapy for Granulicatella adiacens infective endocarditis
S. Khan,
C. Urban,
V. Singh,
D. Liu,
S. Segal-Maurer,
Y. Parmar,
J. Yoon
Affiliations
S. Khan
The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA
C. Urban
The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA; Weill Cornell Medical College, Cornell University, NY, 10065, USA; Corresponding author at: The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA.
V. Singh
Department of Pathology, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA
D. Liu
Department of Pathology, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA
S. Segal-Maurer
The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA; Weill Cornell Medical College, Cornell University, NY, 10065, USA
Y. Parmar
Department of Cardiology, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA
J. Yoon
The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA
Granulicatella adiacens, a nutritionally variant streptococci (NVS) is a well described organism associated with endocarditis. Previously communicated cases have documented the use of double beta-lactam therapy with ampicillin and ceftriaxone to treat patients with infective endocarditis due to Enterococcus faecalis and Streptocossus pneumoniae. We describe the first case of Granulicatella adiacens infective endocarditis in a patient successfully treated with the combination of intravenous ampicillin and ceftriaxone and document their synergistic activity.
