Restructured Mitochondrial-Nuclear Interaction in Plasmodium falciparum Dormancy and Persister Survival after Artemisinin Exposure

Sean V. Connelly; Javier Manzella-Lapeira; Zoë C. Levine; Joseph Brzostowski; Ludmila Krymskaya; Rifat S. Rahman; Angela C. Ellis; Shuchi N. Amin; Juliana M. Sá; Thomas E. Wellems

doi:10.1128/mBio.00753-21

mBio (Jun 2021)

Restructured Mitochondrial-Nuclear Interaction in Plasmodium falciparum Dormancy and Persister Survival after Artemisinin Exposure

Sean V. Connelly,
Javier Manzella-Lapeira,
Zoë C. Levine,
Joseph Brzostowski,
Ludmila Krymskaya,
Rifat S. Rahman,
Angela C. Ellis,
Shuchi N. Amin,
Juliana M. Sá,
Thomas E. Wellems

Affiliations

Sean V. Connelly: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Javier Manzella-Lapeira: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Zoë C. Levine: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Joseph Brzostowski: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Ludmila Krymskaya: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Rifat S. Rahman: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Angela C. Ellis: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Shuchi N. Amin: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Juliana M. Sá: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Thomas E. Wellems: ORCiD; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

DOI: https://doi.org/10.1128/mBio.00753-21
Journal volume & issue: Vol. 12, no. 3

Abstract

Read online

The major first-line treatment for malaria, especially the deadliest form caused by Plasmodium falciparum

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal