Full-length human GLP-1 receptor structure without orthosteric ligands

Fan Wu; Linlin Yang; Kaini Hang; Mette Laursen; Lijie Wu; Gye Won Han; Qiansheng Ren; Nikolaj Kulahin Roed; Guangyao Lin; Michael A. Hanson; Hualiang Jiang; Ming-Wei Wang; Steffen Reedtz-Runge; Gaojie Song; Raymond C. Stevens

doi:10.1038/s41467-020-14934-5

Nature Communications (Mar 2020)

Full-length human GLP-1 receptor structure without orthosteric ligands

Fan Wu,
Linlin Yang,
Kaini Hang,
Mette Laursen,
Lijie Wu,
Gye Won Han,
Qiansheng Ren,
Nikolaj Kulahin Roed,
Guangyao Lin,
Michael A. Hanson,
Hualiang Jiang,
Ming-Wei Wang,
Steffen Reedtz-Runge,
Gaojie Song,
Raymond C. Stevens

Affiliations

Fan Wu: iHuman Institute, ShanghaiTech University
Linlin Yang: Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University
Kaini Hang: iHuman Institute, ShanghaiTech University
Mette Laursen: Novo Nordisk A/S, Novo Nordisk Park
Lijie Wu: School of Life Science and Technology, ShanghaiTech University
Gye Won Han: Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California
Qiansheng Ren: Novo Nordisk Research Center
Nikolaj Kulahin Roed: Novo Nordisk A/S, Novo Nordisk Park
Guangyao Lin: School of Life Science and Technology, ShanghaiTech University
Michael A. Hanson: GPCR Consortium
Hualiang Jiang: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Ming-Wei Wang: School of Life Science and Technology, ShanghaiTech University
Steffen Reedtz-Runge: Novo Nordisk A/S, Novo Nordisk Park
Gaojie Song: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
Raymond C. Stevens: iHuman Institute, ShanghaiTech University

DOI: https://doi.org/10.1038/s41467-020-14934-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

Glucagon-like peptide-1 receptor (GLP-1R) plays an important role in glucose homeostasis and treatment of type 2 diabetes. Here authors report the peptide-free crystal structure of human GLP-1R in an inactive state which reveals a unique closed conformation of the extracellular domain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal