MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure

Chiara Costa; Michele Teodoro; Carmela Alessandra Rugolo; Carmela Alibrando; Federica Giambò; Giusi Briguglio; Concettina Fenga

Toxicology Reports (Jan 2020)

MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure

Chiara Costa,
Michele Teodoro,
Carmela Alessandra Rugolo,
Carmela Alibrando,
Federica Giambò,
Giusi Briguglio,
Concettina Fenga

Affiliations

Chiara Costa: Clinical and Experimental Medicine Department, University of Messina, Messina 98125, Italy
Michele Teodoro: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy
Carmela Alessandra Rugolo: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy
Carmela Alibrando: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy
Federica Giambò: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy
Giusi Briguglio: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy
Concettina Fenga: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy; Corresponding author at: Department of Biomedical and Dental Sciences and Morpho-functional Imaging, Occupational Medicine Section, University of Messina, Policlinico Universitario “G. Martino” – pad. H, Via Consolare Valeria 1, 98125, Messina, Italy.

Journal volume & issue: Vol. 7
pp. 759 – 767

Abstract

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This review summarizes the current knowledge linking cancer and neuro-degenerative diseases to dysregulation of microRNA network following pesticide exposure. Most findings revealed differential miRNA expression targeting biomolecules and pathways involved in various neoplastic localizations and neurodegenerative diseases.A growing body of evidence in recent literature indicates that alteration of specific miRNAs can represent an early biomarker of disease following exposure to chemical agents, including pesticides. Different miRNAs seem to regulate cell proliferation, apoptosis, migration, invasion, and metastasis via many biological pathways through modulation of the expression of target mRNAs.The evaluation of miRNA expression levels may be used to develop new non-invasive strategies for the prediction and prognosis of many diseases, including cancer. However, the application of miRNAs as diagnostic and therapeutic biomarkers in the clinical field is extremely challenging.

Published in Toxicology Reports

ISSN: 2214-7500 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Public aspects of medicine: Toxicology. Poisons
Website: http://www.journals.elsevier.com/toxicology-reports/

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