Impact of epicardial adipose tissue thickness on coronary artery thrombus burden in patients with ST segment elevation myocardial infarction treated by primary percutaneous coronary interventions

Abstract

Objectives Coronary artery thrombus burden (TB) is one of the risk factors for major adverse cardiovascular events (MACE) in patients with acute ST segment elevation myocardial infarction (STEMI). It was discovered that there is a strong relationship between epicardial adipose tissue (EAT) thickness and the incidence of coronary atherosclerosis. The aim of our study is to evaluate the relationship between EAT thickness and coronary TB in patients with STEMI treated with primary percutaneous coronary interventions (PPCI).Methods The study included 80 patients presented with acute STEMI and treated by PPCI; their mean age was 54.35 ± 8.80 years, and 70 (87.5%) were males. Patients were divided into 2 groups according to the degree of TB: group I (25 patients) with low TB and group II (55 patients) with high TB. The EAT thickness was measured by 2D-echocardiography in all patients.Results We found that EAT thickness was significantly higher in group II compared to group I (p < 0.001), and theROC curve cutoff point value of EAT thickness equal to or greater than 2.48 mm could predict high TB in patients with STEMI (p < 0.001), and by multivariate analysis, EAT thickness was the most significant predictor of high TB.Conclusions In STEMI patients undergoing primary PCI, the increased EAT thickness measured by 2D echocardiography is significantly associated with a high coronary artery thrombus burden.

Keywords

• Epicardial adipose tissue
• thrombus burden
• STEMI
• primary percutaneous coronary interventions