Emerging Infectious Diseases (Jun 2015)

Global Burden of Invasive Nontyphoidal Salmonella Disease, 2010

  • Trong T. Ao,
  • Nicholas A. Feasey,
  • Melita A. Gordon,
  • Karen H. Keddy,
  • Frederick J. Angulo,
  • John A. Crump

DOI
https://doi.org/10.3201/eid2106.140999
Journal volume & issue
Vol. 21, no. 6
pp. 941 – 949

Abstract

Read online

Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected and malnourished children are at increased risk for the disease. We conducted a systematic literature review to obtain age group–specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1–6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30–94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, had the highest incidence (227 cases [range 152–341] per 100,000 population) and number of cases (1.9 [range 1.3–2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164–1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.

Keywords