Modification of Polyvinyl Pyrrolidinone, Chitosan with Paracetamol As a Drug Carrier Polymer

Abstract

The drug polymer was prepared by modification of polyvinylpyrrolidinone (PVP) with paracetamol through ester group formation, and partially ring opening of PVP with paracetomol, could let the chitosan to graft on other rings of PVP. Also the NH2 group of chitosan was reacted with PVP produced a new copolymer biopolymer; the prepared polymers were characterized by UV, FT-IR,1H-NMR Spectroscopies, DSC thermal analysis was carried out. Controlled drug release was studied in different PH values. The physical properties and intrinsic viscosity were measured. The work aimed to prolong the sustainable drug delivery system.