Cardiac cellular diversity and functionality in cardiac repair by single-cell transcriptomics

Wei Chen; Wei Chen; Chuling Li; Chuling Li; Yijin Chen; Yijin Chen; Jianping Bin; Jianping Bin; Yanmei Chen; Yanmei Chen; Yanmei Chen

doi:10.3389/fcvm.2023.1237208

Frontiers in Cardiovascular Medicine (Oct 2023)

Cardiac cellular diversity and functionality in cardiac repair by single-cell transcriptomics

Wei Chen,
Wei Chen,
Chuling Li,
Chuling Li,
Yijin Chen,
Yijin Chen,
Jianping Bin,
Jianping Bin,
Yanmei Chen,
Yanmei Chen,
Yanmei Chen

Affiliations

Wei Chen: Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China
Wei Chen: Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China
Chuling Li: Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China
Chuling Li: Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China
Yijin Chen: Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China
Yijin Chen: Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China
Jianping Bin: Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China
Jianping Bin: Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China
Yanmei Chen: Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China
Yanmei Chen: Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China
Yanmei Chen: Department of Cardiology, Ganzhou People’s Hospital, Ganzhou, China

DOI: https://doi.org/10.3389/fcvm.2023.1237208
Journal volume & issue: Vol. 10

Abstract

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Cardiac repair after myocardial infarction (MI) is orchestrated by multiple intrinsic mechanisms in the heart. Identifying cardiac cell heterogeneity and its effect on processes that mediate the ischemic myocardium repair may be key to developing novel therapeutics for preventing heart failure. With the rapid advancement of single-cell transcriptomics, recent studies have uncovered novel cardiac cell populations, dynamics of cell type composition, and molecular signatures of MI-associated cells at the single-cell level. In this review, we summarized the main findings during cardiac repair by applying single-cell transcriptomics, including endogenous myocardial regeneration, myocardial fibrosis, angiogenesis, and the immune microenvironment. Finally, we also discussed the integrative analysis of spatial multi-omics transcriptomics and single-cell transcriptomics. This review provided a basis for future studies to further advance the mechanism and development of therapeutic approaches for cardiac repair.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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