Communications Biology (2021-04-01)

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

  • Kushal Suryamohan,
  • Devan Diwanji,
  • Eric W. Stawiski,
  • Ravi Gupta,
  • Shane Miersch,
  • Jiang Liu,
  • Chao Chen,
  • Ying-Ping Jiang,
  • Frederic A. Fellouse,
  • J. Fah Sathirapongsasuti,
  • Patrick K. Albers,
  • Tanneeru Deepak,
  • Reza Saberianfar,
  • Aakrosh Ratan,
  • Gavin Washburn,
  • Monika Mis,
  • Devi Santhosh,
  • Sneha Somasekar,
  • G. H. Hiranjith,
  • Derek Vargas,
  • Sangeetha Mohan,
  • Sameer Phalke,
  • Boney Kuriakose,
  • Aju Antony,
  • Mart Ustav Jr,
  • Stephan C. Schuster,
  • Sachdev Sidhu,
  • Jagath R. Junutula,
  • Natalia Jura,
  • Somasekar Seshagiri

DOI
https://doi.org/10.1038/s42003-021-02030-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

Read online

Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2.