Aktivitas imunostimulan ekstrak bawang putih tunggal pada mencit yang diinduksi Escherichia coli

Abstract

Single garlic has been used as traditional medicine for increasing stamina. This research aim was to know the effect of single garlic as immunostimulant through activity and phagosytosis capacity of macrophage and weight of mice spleen that induced by E.coli. Male mice (Balb-C, 12 weeks old, weight 20 ± 5 g) was treated by single garlic extract for 28th days (once per days) with various dosage (N 0%, P1 0.25%, P2 0.5%, P3 1%, and P4 2%). On day 29, mice were induced by E.coli through intraperitoneal injection (1 mL, 1.5 x 105 cfu/mL). phagocytosis activity of macrophage was counted by peritoneum liquid smear. Single garlic extract increase amount and capacity of active macrophage in P2, P3, and P4 (p=0,000;α=0.05) with significant various spleen weight (p=0.000;α=0.05). The result showed that the higher dose of single garlic extract can make higher activity and capacity of phagocytosis of macrophage and lower spleen weight.

Keywords

• single garlic
• macrophage
• immunostimulant.