Nature Communications (Nov 2016)

Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide

  • Yukun Wang,
  • Charles H. Chen,
  • Dan Hu,
  • Martin B. Ulmschneider,
  • Jakob P. Ulmschneider

DOI
https://doi.org/10.1038/ncomms13535
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Antimicrobial peptides (AMPs) selectively form pores in microbial membranes in process not fully understood. Here the authors use experimentally guided molecular dynamics to study maculatin pore formation, showing how this AMP assembles into transient and structurally diverse oligomeric pores in cell membranes.