Nature Communications (May 2016)
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms
- Emma Mitchell,
- Shifra L. Klein,
- Kimon V. Argyropoulos,
- Ali Sharma,
- Robin B. Chan,
- Judit Gal Toth,
- Luendreo Barboza,
- Charlotte Bavley,
- Analia Bortolozzi,
- Qiuying Chen,
- Bingfang Liu,
- Joanne Ingenito,
- Willie Mark,
- Jarrod Dudakov,
- Steven Gross,
- Gilbert Di Paolo,
- Francesc Artigas,
- Marcel van den Brink,
- Miklos Toth
Affiliations
- Emma Mitchell
- Department of Pharmacology, Weill Cornell Medical College
- Shifra L. Klein
- Department of Pharmacology, Weill Cornell Medical College
- Kimon V. Argyropoulos
- Department of Immunology, Memorial Sloan Kettering Cancer Center
- Ali Sharma
- Department of Pharmacology, Weill Cornell Medical College
- Robin B. Chan
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Judit Gal Toth
- Department of Pharmacology, Weill Cornell Medical College
- Luendreo Barboza
- Department of Pharmacology, Weill Cornell Medical College
- Charlotte Bavley
- Department of Pharmacology, Weill Cornell Medical College
- Analia Bortolozzi
- Department of Neurochemistry and Neuropharmacology, Institut d’Investigacions Biomèdiques de Barcelona (IIBB-CSIC)
- Qiuying Chen
- Department of Pharmacology, Weill Cornell Medical College
- Bingfang Liu
- Department of Pharmacology, Weill Cornell Medical College
- Joanne Ingenito
- Mouse Genetics Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Willie Mark
- Mouse Genetics Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
- Jarrod Dudakov
- Department of Immunology, Memorial Sloan Kettering Cancer Center
- Steven Gross
- Department of Pharmacology, Weill Cornell Medical College
- Gilbert Di Paolo
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Francesc Artigas
- Department of Neurochemistry and Neuropharmacology, Institut d’Investigacions Biomèdiques de Barcelona (IIBB-CSIC)
- Marcel van den Brink
- Department of Immunology, Memorial Sloan Kettering Cancer Center
- Miklos Toth
- Department of Pharmacology, Weill Cornell Medical College
- DOI
- https://doi.org/10.1038/ncomms11492
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Physiological effects of psychological stress and infection in mothers can increase the incidence of anxiety and psychiatric diseases in offsprings and in subsequent generation. Here, Miklos Toth and colleagues show that intergenerational inheritance of neurological traits is propagated across multiple generations independently by parallel non-genetic mechanisms involving independent segregation of epigenetic specific loci.
