circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis

Haibin Xia; Boyang Liu; Nanxiang Shen; Jinhua Xue; Siyu Chen; Hongbo Guo; Xiaozhong Zhou

Molecular Therapy: Nucleic Acids (Mar 2022)

circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis

Haibin Xia,
Boyang Liu,
Nanxiang Shen,
Jinhua Xue,
Siyu Chen,
Hongbo Guo,
Xiaozhong Zhou

Affiliations

Haibin Xia: Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, 250 Chang-gang East Road, Guangzhou 510260, China; Trauma Center, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China
Boyang Liu: Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
Nanxiang Shen: Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, 250 Chang-gang East Road, Guangzhou 510260, China
Jinhua Xue: Department of Physiology, School of Basic Medical Sciences, Gannan Medical University, Ganzhou 341000, China
Siyu Chen: Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University, 250 Chang-gang East Road, Guangzhou 510260, China
Hongbo Guo: Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; Corresponding author: Hongbo Guo, Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Xiaozhong Zhou: Trauma Center, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China; Corresponding author: Xiaozhong Zhou, Trauma Center, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.

Journal volume & issue: Vol. 27
pp. 1 – 15

Abstract

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Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear. In this study, we found that circRNA-0002109 was highly expressed in glioma tissues and cell lines. Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors in vivo. Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (miR-129-5P), which partially alleviated the inhibitory effect of miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma. Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma.

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

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