Nature Communications (Mar 2023)
SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity
- Jillian R. Jaycox,
- Carolina Lucas,
- Inci Yildirim,
- Yile Dai,
- Eric Y. Wang,
- Valter Monteiro,
- Sandra Lord,
- Jeffrey Carlin,
- Mariko Kita,
- Jane H. Buckner,
- Shuangge Ma,
- Melissa Campbell,
- Albert Ko,
- Saad Omer,
- Carrie L. Lucas,
- Cate Speake,
- Akiko Iwasaki,
- Aaron M. Ring
Affiliations
- Jillian R. Jaycox
- Department of Immunobiology, Yale School of Medicine
- Carolina Lucas
- Department of Immunobiology, Yale School of Medicine
- Inci Yildirim
- Department of Pediatrics, Section of Infectious Diseases and Global Health, Yale University School of Medicine
- Yile Dai
- Department of Immunobiology, Yale School of Medicine
- Eric Y. Wang
- Department of Immunobiology, Yale School of Medicine
- Valter Monteiro
- Department of Immunobiology, Yale School of Medicine
- Sandra Lord
- Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
- Jeffrey Carlin
- Virginia Mason Medical Center
- Mariko Kita
- Virginia Mason Medical Center
- Jane H. Buckner
- Translational Research Program, Benaroya Research Institute at Virginia Mason
- Shuangge Ma
- Department of Biostatistics, Yale School of Public Health
- Melissa Campbell
- Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine
- Albert Ko
- Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine
- Saad Omer
- Yale Institute for Global Health, Yale University
- Carrie L. Lucas
- Department of Immunobiology, Yale School of Medicine
- Cate Speake
- Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
- Akiko Iwasaki
- Department of Immunobiology, Yale School of Medicine
- Aaron M. Ring
- Department of Immunobiology, Yale School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36686-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 9
Abstract
Whilst SARS-CoV-2 mRNA vaccines have demonstrated efficacy in reducing infection severity, research has shown that SARS-CoV-2 infection is associated with new autoantibodies. Whether this would also be observed during mRNA vaccination is unclear. Here, the authors use an autoantibody screening platform to monitor autoantibody responses in a diverse cohort during vaccination.
