P1354: CRISPR/CAS9 GENE EDITING OF IMMUNE CHECKPOINT RECEPTOR NKG2A IMPROVES THE ANTI-LEUKEMIC EFFICACY OF PRIMARY CD33-TARGETING CAR-NK CELLS.

• Nawid Albinger,
• Tobias Bexte,
• Ahmad Al-Ajami,
• Philipp Wendel,
• Leon Buchinger,
• Alec Gessner,
• Jamal Alzubi,
• Vinzenz Särchen,
• Meike Vogler,
• Raj Bhayadia,
• Jan-Henning Klusmann,
• Nina Möker,
• Toni Cathomen,
• Michael A. Rieger,
• Katharina Imkeller,
• Evelyn Ullrich

Affiliations

Nawid Albinger

1 University Hospital Frankfurt, Children’s Hospital, Experimental Immunology, Frankfurt am Main, Germany

Tobias Bexte

1 University Hospital Frankfurt, Children’s Hospital, Experimental Immunology, Frankfurt am Main, Germany

Ahmad Al-Ajami

2 University Hospital Frankfurt, Neurological Institute/ Edinger Institute, Frankfurt am Main, Germany

Philipp Wendel

1 University Hospital Frankfurt, Children’s Hospital, Experimental Immunology, Frankfurt am Main, Germany

Leon Buchinger

1 University Hospital Frankfurt, Children’s Hospital, Experimental Immunology, Frankfurt am Main, Germany

Alec Gessner

3 University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany

Jamal Alzubi

4 Medical Center – University of Freiburg, Center for Chronic Immunodeficiency, Freiburg im Breisgau, Germany

Vinzenz Särchen

5 Institute for Experimental Cancer Research in Pediatrics, Frankfurt am Main, Germany

Meike Vogler

5 Institute for Experimental Cancer Research in Pediatrics, Frankfurt am Main, Germany

Raj Bhayadia

6 University Hospital Frankfurt, Children’s Hospital, Frankfurt am Main, Germany

Jan-Henning Klusmann

6 University Hospital Frankfurt, Children’s Hospital, Frankfurt am Main, Germany

Nina Möker

7 Miltenyi Biotec, Bergisch Gladbach, Germany

Toni Cathomen

4 Medical Center – University of Freiburg, Center for Chronic Immunodeficiency, Freiburg im Breisgau, Germany

Michael A. Rieger

3 University Hospital Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany

Katharina Imkeller

2 University Hospital Frankfurt, Neurological Institute/ Edinger Institute, Frankfurt am Main, Germany

Evelyn Ullrich

1 University Hospital Frankfurt, Children’s Hospital, Experimental Immunology, Frankfurt am Main, Germany