Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

Jifei Miao; Jifei Miao; Haixia Ma; Yang Yang; Yuanpin Liao; Cui Lin; Juanxia Zheng; Muli Yu; Jiao Lan

doi:10.3389/fnagi.2023.1201982

Frontiers in Aging Neuroscience (Jun 2023)

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

Jifei Miao,
Jifei Miao,
Haixia Ma,
Yang Yang,
Yuanpin Liao,
Cui Lin,
Juanxia Zheng,
Muli Yu,
Jiao Lan

Affiliations

Jifei Miao: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China
Jifei Miao: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
Haixia Ma: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China
Yang Yang: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China
Yuanpin Liao: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China
Cui Lin: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China
Juanxia Zheng: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China
Muli Yu: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China
Jiao Lan: Shenzhen Bao’an Traditional Chinese Medicine Hospital, Shenzhen, China

DOI: https://doi.org/10.3389/fnagi.2023.1201982
Journal volume & issue: Vol. 15

Abstract

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by protein aggregation in the brain. Recent studies have revealed the critical role of microglia in AD pathogenesis. This review provides a comprehensive summary of the current understanding of microglial involvement in AD, focusing on genetic determinants, phenotypic state, phagocytic capacity, neuroinflammatory response, and impact on synaptic plasticity and neuronal regulation. Furthermore, recent developments in drug discovery targeting microglia in AD are reviewed, highlighting potential avenues for therapeutic intervention. This review emphasizes the essential role of microglia in AD and provides insights into potential treatments.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

About the journal

Abstract

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