Nature Communications (Aug 2021)
The developing mouse coronal suture at single-cell resolution
- D’Juan T. Farmer,
- Hana Mlcochova,
- Yan Zhou,
- Nils Koelling,
- Guanlin Wang,
- Neil Ashley,
- Helena Bugacov,
- Hung-Jhen Chen,
- Riana Parvez,
- Kuo-Chang Tseng,
- Amy E. Merrill,
- Robert E. Maxson,
- Andrew O. M. Wilkie,
- J. Gage Crump,
- Stephen R. F. Twigg
Affiliations
- D’Juan T. Farmer
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Hana Mlcochova
- Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Yan Zhou
- Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Nils Koelling
- Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Guanlin Wang
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Neil Ashley
- Single cell facility, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Helena Bugacov
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Hung-Jhen Chen
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Riana Parvez
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Kuo-Chang Tseng
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Amy E. Merrill
- Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California
- Robert E. Maxson
- Department of Biochemistry, Keck School of Medicine, University of Southern California
- Andrew O. M. Wilkie
- Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- J. Gage Crump
- Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California
- Stephen R. F. Twigg
- Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-021-24917-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The development of the coronal suture remains incompletely understood. Here the authors perform scRNA-seq and expression validation to uncover the cellular diversity within the murine embryonic coronal suture, thus revealing possible mechanisms for its loss in craniosynostosis.
