Nature Communications (Dec 2019)

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution

  • Loukia G. Karacosta,
  • Benedict Anchang,
  • Nikolaos Ignatiadis,
  • Samuel C. Kimmey,
  • Jalen A. Benson,
  • Joseph B. Shrager,
  • Robert Tibshirani,
  • Sean C. Bendall,
  • Sylvia K. Plevritis

DOI
https://doi.org/10.1038/s41467-019-13441-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Intermediate transitions between epithelial and mesenchymal states are associated with tumor progression. Here using mass cytometry, Plevritis and colleagues develop a computational framework to resolve and map these trajectories in lung cancer cells and clinical specimens.