Urology Case Reports (Sep 2015)

ALK Gene Translocation in Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report

  • Kimiaki Takagi,
  • Manabu Takai,
  • Koji Kameyama,
  • Kengo Horie,
  • Mina Kikuchi,
  • Taku Kato,
  • Kosuke Mizutani,
  • Kensaku Seike,
  • Tomohiro Tsuchiya,
  • Mitsuru Yasuda,
  • Shigeaki Yokoi,
  • Natsuko Suzui,
  • Masahiro Nakano,
  • Takashi Deguchi

DOI
https://doi.org/10.1016/j.eucr.2015.06.003
Journal volume & issue
Vol. 3, no. 5
pp. 138 – 140

Abstract

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A 26-year-old woman with gross hematuria was seen in a previous hospital. Magnetic resonance imaging (MRI) showed a tumor at the dome of the urinary bladder with invasion outside of the bladder wall. The patient underwent transurethral resection of the bladder tumor (TUR-BT). From the result of the pathological examination, the tumor was suggested to be carcinosarcoma of the bladder. The patient was then referred to our hospital for treatment. We performed radical cystectomy and ileal conduit diversion. Pathological examination of the excised specimen revealed an inflammatory myofibroblastic tumor as the basis for immunostaining of anaplastic lymphoma kinase (ALK).

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