Virology Journal (Nov 2024)
Genomic epidemiology of early SARS-CoV-2 transmission dynamics in Bangladesh
- L. Carnegie,
- J. T. McCrone,
- L. du Plessis,
- M. Hasan,
- M.Z. Ali,
- R. Begum,
- M.Z. Hassan,
- S. Islam,
- M.H. Rahman,
- A.S.M. Uddin,
- M.S. Sarker,
- T. Das,
- M. Hossain,
- M. Khan,
- M.H. Razu,
- A. Akram,
- S. Arina,
- E. Hoque,
- M.M.A. Molla,
- T. Nafisaa,
- P. Angra,
- A. Rambaut,
- S.T. Pullan,
- K.L. Osman,
- M.A. Hoque,
- P. Biswas,
- M.S. Flora,
- J. Raghwani,
- G. Fournié,
- M.A. Samad,
- S.C. Hill
Affiliations
- L. Carnegie
- Department of Pathobiology and Population Sciences, Royal Veterinary College (RVC)
- J. T. McCrone
- Institute of Ecology and Evolution, University of Edinburgh
- L. du Plessis
- Department of Biosystems Science and Engineering, ETH Zürich
- M. Hasan
- Bangladesh Livestock Research Institute (BLRI)
- M.Z. Ali
- Bangladesh Livestock Research Institute (BLRI)
- R. Begum
- Bangladesh Livestock Research Institute (BLRI)
- M.Z. Hassan
- Bangladesh Livestock Research Institute (BLRI)
- S. Islam
- Bangladesh Livestock Research Institute (BLRI)
- M.H. Rahman
- Bangladesh Livestock Research Institute (BLRI)
- A.S.M. Uddin
- Bangladesh Livestock Research Institute (BLRI)
- M.S. Sarker
- Bangladesh Livestock Research Institute (BLRI)
- T. Das
- Chattogram Veterinary and Animal Sciences University (CVASU)
- M. Hossain
- NSU Genome Research Institute (NGRI), North South University
- M. Khan
- Bangladesh Reference Institute for Chemical Measurements (BRiCM)
- M.H. Razu
- Bangladesh Reference Institute for Chemical Measurements (BRiCM)
- A. Akram
- National Institute of Laboratory Medicine and Referral Centre (NILMRC)
- S. Arina
- National Institute of Laboratory Medicine and Referral Centre (NILMRC)
- E. Hoque
- National Institute of Laboratory Medicine and Referral Centre (NILMRC)
- M.M.A. Molla
- National Institute of Laboratory Medicine and Referral Centre (NILMRC)
- T. Nafisaa
- National Institute of Laboratory Medicine and Referral Centre (NILMRC)
- P. Angra
- Centers for Disease Control and Prevention (CDC)
- A. Rambaut
- Institute of Ecology and Evolution, University of Edinburgh
- S.T. Pullan
- United Kingdom Health Security Agency (UKHSA)
- K.L. Osman
- United Kingdom Health Security Agency (UKHSA)
- M.A. Hoque
- Chattogram Veterinary and Animal Sciences University (CVASU)
- P. Biswas
- Chattogram Veterinary and Animal Sciences University (CVASU)
- M.S. Flora
- National Institute of Preventive and Social Medicine (NIPSOM), Ministry of Health and Family Welfare
- J. Raghwani
- Department of Pathobiology and Population Sciences, Royal Veterinary College (RVC)
- G. Fournié
- Department of Pathobiology and Population Sciences, Royal Veterinary College (RVC)
- M.A. Samad
- Bangladesh Livestock Research Institute (BLRI)
- S.C. Hill
- Department of Pathobiology and Population Sciences, Royal Veterinary College (RVC)
- DOI
- https://doi.org/10.1186/s12985-024-02560-2
- Journal volume & issue
-
Vol. 21,
no. 1
pp. 1 – 13
Abstract
Abstract Background Genomic epidemiology has helped reconstruct the global and regional movement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is still a lack of understanding of SARS-CoV-2 spread in some of the world’s least developed countries (LDCs). Methods To begin to address this disparity, we studied the transmission dynamics of the virus in Bangladesh during the country’s first COVID-19 wave by analysing case reports and whole-genome sequences from all eight divisions of the country. Results We detected > 50 virus introductions to the country during the period, including during a period of national lockdown. Additionally, through discrete phylogeographic analyses, we identified that geographical distance and population -density and/or -size influenced virus spatial dispersal in Bangladesh. Conclusions Overall, this study expands our knowledge of SARS-CoV-2 genomic epidemiology in Bangladesh, shedding light on crucial transmission characteristics within the country, while also acknowledging resemblances and differences to patterns observed in other nations.
Keywords
