Analysis on the effect of anti-VEGF drugs on IOP, BCVA and mfERG changes in patients with idiopathic CNV

Abstract

AIM: To investigate the efficacy of anti-vascular endothelial growth factor(VEGF)drugs in the treatment of choroidal neovascularization(CNV)and its effects on intraocular pressure, best corrected visual acuity(BCVA)and multifocal electroretinogram(mfERG). METHODS:Totally 44 cases(44 eyes)of idiopathic CNV patients treated in our hospital from February 2015 to January 2017 were selected. All patients were treated with intravitreal injection of anti-VEGF. BCVA, intraocular pressure, mfERG and central retinal thickness(CRT)were observed after treatment. RESULTS: At 1 and 3mo after treatment, BCVA and CRT were significantly improved than those before treatment(PPP>0.05). At 1 and 3mo after treatment, amplitudes of Ring1, Ring2 and Ring4 NI-P1 were higher than those before treatment(PPPP>0.05). CONCLUSION: Anti-VEGF drugs are effective in the treatment of idiopathic CNV, which can improve vision and macular retinal function, decrease the retinal thickness, and do not affect the intraocular pressure.

Keywords

• vascular endothelial growth factor
• choroidal neovascularization
• best corrected visual acuity
• intraocular pressure
• multifocal electroretinogram
• multifocal electroretinogram