Nature Communications (Jul 2019)

Molecular mechanism of cytoplasmic dynein tension sensing

  • Lu Rao,
  • Florian Berger,
  • Matthew P. Nicholas,
  • Arne Gennerich

DOI
https://doi.org/10.1038/s41467-019-11231-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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The cytoplasmic motor protein dynein senses directional tension; its microtubule-binding domains bind microtubules more strongly when under backward load. Here the authors use optical tweezers to show that the linker, buttress, and stalk domains together regulate directional tension-sensing.