IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

Biying Huang; Biying Huang; Long Wang; Long Wang; Long Wang; Long Wang; Kui Tang; Kui Tang; Sijie Chen; Sijie Chen; Yan Xu; Yan Xu; Haiqin Liao; Haiqin Liao; Chengcheng Niu; Chengcheng Niu

doi:10.3389/fchem.2022.840598

Frontiers in Chemistry (Jan 2022)

IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

Biying Huang,
Biying Huang,
Long Wang,
Long Wang,
Long Wang,
Long Wang,
Kui Tang,
Kui Tang,
Sijie Chen,
Sijie Chen,
Yan Xu,
Yan Xu,
Haiqin Liao,
Haiqin Liao,
Chengcheng Niu,
Chengcheng Niu

Affiliations

Biying Huang: Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China
Biying Huang: Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China
Long Wang: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China
Long Wang: Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, China
Long Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Long Wang: Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
Kui Tang: Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China
Kui Tang: Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China
Sijie Chen: Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China
Sijie Chen: Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China
Yan Xu: Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China
Yan Xu: Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China
Haiqin Liao: Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China
Haiqin Liao: Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China
Chengcheng Niu: Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China
Chengcheng Niu: Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fchem.2022.840598
Journal volume & issue: Vol. 10

Abstract

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Multidrug-resistant (MDR) bacterial strains have emerged and weakened the therapeutic effects of antibacterial drugs. Sonodynamic therapy (SDT) takes advantage of noninvasiveness and deep tissue-penetrating features and has been rejuvenated to combat MDR bacteria and their biofilm-associated infections. To improve the efficacy of antibacterial SDT, we first developed IR780-based PLGA nanoparticles as sonosensitizers for high-frequency ultrasound (US)-monitored antibacterial SDT of MRSA myositis by therapeutic low-frequency US. In this study, the developed shell-core-structured IR780@PLGA nanoparticles were designed with a polymer shell PLGA with the sonosensitizer IR780 loaded on. High-frequency diagnostic US was introduced to monitor the sonotherapeutic progression of bacterial myositis by therapeutic low-frequency US. Importantly, the in vitro and in vivo results confirmed that IR780@PLGA nanoparticles combined with US irradiation possess high efficiency for antibacterial therapy. This approach provides a simple and efficient strategy to monitor and combat MDR bacterial infection.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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