The Study of [3H]-Cycloprolylglycine Pharmacokinetics in Rat Blood

Abstract

Resume. The objective of this study is to evaluate pharmacokinetic parameters of tritium-labeled cycloprolylglycine [3H] -CPG following intravenous bolus administration of 5.7 μg (2 mCi). [3H] -CPG was prepared by solid-state catalytic isotopic exchange with spillover-tritium. It was found that plasma concentration-time profile of [3H] -CPG is adequately fit by a two-compartment model. The pharmacokinetic parameter estimates revealed rapid а-phase (distribution phase) (T1/2α min) followed by a slower β-phase of elimination (T1/2β 80 min). These findings are consistent with previous results of pharmacokinetic study of CPG as a noopept metabolite. CPG is differ significantly from other therapeutic peptides in pharmacokinetic profile (T1/2 , MRT, etc), which implies that CPG has a more prolonged duration of action.

Keywords

• циклопролилглицин (цпг)
• фармакокинетика [³н]-цпг
• фармакокинетическое моделирование
• фармакокинетические параметры
• крысы
• кровь
• cycloprolylglycine (cpg)
• pharmacokinetics
• [³h] -cpg
• pharmacokinetic modeling
• pharmacokinetic parameters
• rats
• blood