AMPKα2 controls the anti-atherosclerotic effects of fish oils by modulating the SUMOylation of GPR120

Abstract

Consuming fish oil is linked to reduced risk of cardiovascular disease in some populations, but the effects are not consistent across studies. Here the authors report that smooth muscle cell AMPKα2 is required for the protective effects of fish oil on atherosclerosis in mice, and acts via post-translational regulation of the fatty acid receptor GPR120.