Nature Communications (Oct 2021)
Determinants of renal cell carcinoma invasion and metastatic competence
- Kangsan Kim,
- Qinbo Zhou,
- Alana Christie,
- Christina Stevens,
- Yuanqing Ma,
- Oreoluwa Onabolu,
- Suneetha Chintalapati,
- Tiffani Mckenzie,
- Vanina Toffessi Tcheuyap,
- Layton Woolford,
- He Zhang,
- Nirmish Singla,
- Pravat Kumar Parida,
- Mauricio Marquez-Palencia,
- Ivan Pedrosa,
- Vitaly Margulis,
- Arthur Sagalowsky,
- Zhiqun Xie,
- Tao Wang,
- Steffen Durinck,
- Zora Modrusan,
- Somasekar Seshagiri,
- Payal Kapur,
- James Brugarolas,
- Srinivas Malladi
Affiliations
- Kangsan Kim
- Department of Pathology, University of Texas Southwestern Medical Center
- Qinbo Zhou
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center
- Alana Christie
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Christina Stevens
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Yuanqing Ma
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Oreoluwa Onabolu
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Suneetha Chintalapati
- Department of Pathology, University of Texas Southwestern Medical Center
- Tiffani Mckenzie
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Vanina Toffessi Tcheuyap
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Layton Woolford
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- He Zhang
- Bioinformatics Core Facility, The University of Texas Southwestern Medical Center
- Nirmish Singla
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Pravat Kumar Parida
- Department of Pathology, University of Texas Southwestern Medical Center
- Mauricio Marquez-Palencia
- Department of Pathology, University of Texas Southwestern Medical Center
- Ivan Pedrosa
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Vitaly Margulis
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Arthur Sagalowsky
- Department of Urology, The University of Texas Southwestern Medical Center
- Zhiqun Xie
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center
- Tao Wang
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center
- Steffen Durinck
- Molecular Biology Department, Genentech, Inc.
- Zora Modrusan
- Molecular Biology Department, Genentech, Inc.
- Somasekar Seshagiri
- Molecular Biology Department, Genentech, Inc.
- Payal Kapur
- Department of Pathology, University of Texas Southwestern Medical Center
- James Brugarolas
- Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center
- Srinivas Malladi
- Department of Pathology, University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-25918-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using multi-region genomics and in vivo models.
