Nature Communications (Apr 2023)

Amyloid-polysaccharide interfacial coacervates as therapeutic materials

  • Mohammad Peydayesh,
  • Sabrina Kistler,
  • Jiangtao Zhou,
  • Viviane Lutz-Bueno,
  • Francesca Damiani Victorelli,
  • Andréia Bagliotti Meneguin,
  • Larissa Spósito,
  • Tais Maria Bauab,
  • Marlus Chorilli,
  • Raffaele Mezzenga

DOI
https://doi.org/10.1038/s41467-023-37629-z
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 11

Abstract

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Liquid-liquid phase separation offer a strategy for targeting biomaterial scaffolds, but controlling assembly to form functional materials is challenging. Here, the authors transform native proteins into amyloid fibres for assembly, and use the materials as a gastric ulcer protective agent.