ExpLOring the role of the intestinal MiCrobiome in InflammATory bowel disease-AssocIated SpONdylarthritis (LOCATION-IBD)
Madeline Alizadeh,
Uni Wong,
Bernadette C. Siaton,
Seema A. Patil,
Lauren George,
Jean-Pierre Raufman,
William H. Scott,
Erik C. von Rosenvinge,
Jacques Ravel,
Raymond K. Cross
Affiliations
Madeline Alizadeh
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA; Corresponding author. Institute for Genome Sciences HSF III, 670 W Baltimore St Baltimore, MD, 21201, USA.
Uni Wong
Department of Veterans Affairs, Washington DC Veterans Health Administration, Washington DC, USA
Bernadette C. Siaton
Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Seema A. Patil
Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
Lauren George
Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
Jean-Pierre Raufman
Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
William H. Scott
Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
Erik C. von Rosenvinge
Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
Jacques Ravel
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
Raymond K. Cross
Division of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Background: Inflammatory Bowel Disease (IBD)-associated arthritis is a frequent and potentially debilitating complication of IBD, that can affect those with or without active intestinal disease, and is often difficult to treat. The microbiome is known to play a role in IBD development and has been shown to be associated with inflammatory arthritis without concomitant IBD, but its role in IBD-associated arthritis is still unexplored. Further, disease localization is associated with development of IBD-associated arthritis, and stool compositional profiles are predictive of disease localization, yet mucosal location-specific microbiomes have not been well characterized. To address this gap in understanding, we designed a study (LOCATION-IBD) to characterize the mucosa-associated intestinal microbiome and metabolome in IBD-associated arthritis. Methods: Adults with an established diagnosis of IBD undergoing clinical colonoscopy between May of 2021 and February of 2023 were invited to participate in this study; those interested in participation who met inclusion criteria were enrolled. Prior to enrollment, participants were stratified into those with or without IBD-associated arthritis. All participants were interviewed and had clinical and demographic data collected, and 97.8% completed clinical colonoscopy with biopsy collection. Results and conclusion: A total of 182 participants, 53 with confirmed IBD-associated arthritis, were enrolled in this study, resulting in 1151 biopsies obtained for microbiome and metabolome analysis (median 6, mean 6.3 per participant). Clinical and demographic data obtained from the study population will be analyzed with microbiome and metabolome data obtained from biopsies, with the goal of better understanding the mechanisms underpinning the host-microbiome relationship associated the development of IBD-associated arthritis.
