Nature Communications (Nov 2019)

Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model

  • Guillaume Etter,
  • Suzanne van der Veldt,
  • Frédéric Manseau,
  • Iman Zarrinkoub,
  • Emilie Trillaud-Doppia,
  • Sylvain Williams

DOI
https://doi.org/10.1038/s41467-019-13260-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Slow gamma oscillations are associated with memory and have been reported to be disrupted in patients with Alzheimer’s disease. Here the authors show that optogenetic stimulation of medial septum parvalbumin neurons at 40 Hz rescues memory retrieval in the J20 mouse model of Alzheimer’s disease.