Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase

Gita Krievina, MSc; Peteris Tretjakovs, Biol PhD; Ilze Skuja, MD; Vija Silina, MD; Laura Keisa, MD; Daiga Krievina, MSc; Guntis Bahs, MD PhD

doi:10.1016/j.ebiom.2016.10.020

EBioMedicine (Nov 2016)

Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase

Gita Krievina, MSc,
Peteris Tretjakovs, Biol PhD,
Ilze Skuja, MD,
Vija Silina, MD,
Laura Keisa, MD,
Daiga Krievina, MSc,
Guntis Bahs, MD PhD

Affiliations

Gita Krievina, MSc: Riga Stradiņš University, Department of Human Physiology and Biochemistry, 16 Dzirciema Street, LV-1007 Riga, Latvia
Peteris Tretjakovs, Biol PhD: Riga Stradiņš University, Department of Human Physiology and Biochemistry, 16 Dzirciema Street, LV-1007 Riga, Latvia
Ilze Skuja, MD: Riga Stradiņš University, Department of Family Medicine, 16 Dzirciema Street, LV-1007 Riga, Latvia
Vija Silina, MD: Riga Stradiņš University, Department of Family Medicine, 16 Dzirciema Street, LV-1007 Riga, Latvia
Laura Keisa, MD: Riga Stradiņš University, Department of Human Physiology and Biochemistry, 16 Dzirciema Street, LV-1007 Riga, Latvia
Daiga Krievina, MSc: Riga Stradiņš University, Department of Human Physiology and Biochemistry, 16 Dzirciema Street, LV-1007 Riga, Latvia
Guntis Bahs, MD PhD: Riga Stradiņš University, Department of Internal Diseases, 16 Dzirciema Street, LV-1007 Riga, Latvia

DOI: https://doi.org/10.1016/j.ebiom.2016.10.020
Journal volume & issue: Vol. 13, no. C
pp. 274 – 283

Abstract

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Objective: A potential mechanism by which obesity could promote hypertension and kidney diseases is through accumulation of adipose tissue in the renal sinus (RS). The aim of the study was to quantify RS and abdominal adipose tissue volumes and to evaluate serum kidney injury molecule (sKIM)-1 and fibroblast growth factor (FGF)-21 association with different adipose tissue compartments. Methods: The cross-sectional study included 280 and follow-up study-40 asymptomatic participants; aged 38.30 ± 4.10. For all study participants computed tomography examination was performed, sKIM-1 and FGF-21 levels were measured. Results: The results indicated asymmetrical deposition of adipose tissue into the RS even after corresponding kidney volume adjustment. The cross-sectional and the follow-up studies showed that sKIM-1 level was positively associated with RS adipose tissue volume increase for both genders. FGF-21 was positively associated with RS and retroperitoneal adipose tissue amount. Conclusions: Regardless of gender adipose tissue in RS accumulates asymmetrically–the left RS accumulates a significantly higher amount of adipose tissue. Thus, primarily RS adipose tissue effects should be assessed on the left kidney. Accumulation of adipose tissue in the RS is related with the visceral adipose amount, KIM-1 and FGF-21 concentration increase in the blood serum.

Published in EBioMedicine

ISSN: 2352-3964 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: http://www.journals.elsevier.com/ebiomedicine/

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