Changes in levels of neuromarkers and cognitive functioning of patients with treatment-resistant schizophrenia

Abstract

This paper focuses on cognitive functioning in patients with schizophrenia and factors that influence it, including clinical and demographic characteristics and levels of blood biomarkers (neuronspecific enolase and S100B protein). Results of the present study suggest heterogeneity and selectivity of cognitive impairment. Connections between genetic predisposition to schizophrenia and decreased speed of processing, age of onset and the degree of working memory deficits, clinical status features and the speed of skill development, planning, accuracy and impulsivity were established. It was found that the impairment of planning and problem-solving behavior was isolated from other domains. Altered neuronal membrane permeability may contribute to the pathogenesis of memory disorders.

Keywords

• шизофрения
• когнитивное функционирование
• schizophrenia
• cognitive functioning