Frontiers in Oncology (Mar 2021)

In Vivo 3-D Dose Verification Using PET/CT Images After Carbon-Ion Radiation Therapy

  • Lining Sun,
  • Lining Sun,
  • Weigang Hu,
  • Weigang Hu,
  • Songtao Lai,
  • Songtao Lai,
  • Leijun Shi,
  • Junchao Chen,
  • Junchao Chen

DOI
https://doi.org/10.3389/fonc.2021.621394
Journal volume & issue
Vol. 11

Abstract

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ObjectiveTo investigate the usefulness of positron emission tomography (PET) images obtained after carbon-ion irradiation for dose verification in carbon-ion radiotherapy.Methods and MaterialsAn anthropomorphic head phantom was used in this study. Three cubes with volumes of 1, 4, and 10 ml were contoured as targets in the phantom CT through a treatment planning system. Treatment plans with six prescriptions from 2.5 to 10 Gy (2.5, 3, 5, 6, 8, and 10 Gy effective dose) were designed and delivered by 90° fixed carbon-ion beams, respectively. After irradiation of the phantom, a PET/CT scan was performed to fuse the treatment-planning CT image with the PET/CT image. The relationship between target volume and the standard uptake value (SUV) in PET/CT was evaluated for corresponding plan prescription. The MIM Maestro software was used for the image fusion and data analysis.ResultsSUV in the target had an approximate linear relationship with the effective dose. The same effective dose could generate a roughly equal SUV for different target volumes (p < 0.05).ConclusionsIt is feasible to verify the actual 3-D dose distribution of carbon-ion radiotherapy by the approach in this study.

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