BioImpacts (Sep 2020)

Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial

  • Khalil Ansarin,
  • Ramin Tolouian,
  • Mohammadreza Ardalan,
  • Ali Taghizadieh,
  • Mojtaba Varshochi,
  • Soheil Teimouri,
  • Tahere Vaezi,
  • Hamed Valizadeh,
  • Parviz Saleh,
  • Saeid Safiri,
  • Kenneth R. Chapman

DOI
https://doi.org/10.34172/bi.2020.27
Journal volume & issue
Vol. 10, no. 4
pp. 209 – 215

Abstract

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Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19. Methods: An open-label randomized clinical trial study was performed in Tabriz, North-West of Iran. They were randomized to either the treatment with the bromhexine group or the control group, in a 1:1 ratio with 39 patients in each arm. Standard therapy was used in both groups and those patients in the treatment group received oral bromhexine 8 mg three times a day additionally. The primary outcome was a decrease in the rate of ICU admissions, intubation/mechanical ventilation, and mortality. Results: A total of 78 patients with similar demographic and disease characteristics were enrolled. There was a significant reduction in ICU admissions (2 out of 39 vs. 11 out of 39, P = 0.006), intubation (1 out of 39 vs. 9 out of 39, P = 0.007) and death (0 vs. 5, P = 0.027) in the bromhexine treated group compared to the standard group. No patients were withdrawn from the study because of adverse effects. Conclusion: The early administration of oral bromhexine reduces the ICU transfer, intubation, and the mortality rate in patients with COVID-19. This affordable medication can easily be administered everywhere with a huge positive impact(s) on public health and the world economy. Altogether, the verification of our results on a larger scale and different medical centers is strongly recommended. Trial Registration: IRCT202003117046797N4; https://irct.ir/trial/46969.

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