Understanding COVID-19-associated coagulopathy: From PIC to SIC or DIC

Zhong Wang; Xiang Gao; He Miao; Xiaochun Ma; Renyu Ding

doi:10.1016/j.jointm.2021.03.002

Journal of Intensive Medicine (Jul 2021)

Understanding COVID-19-associated coagulopathy: From PIC to SIC or DIC

Zhong Wang,
Xiang Gao,
He Miao,
Xiaochun Ma,
Renyu Ding

Affiliations

Zhong Wang: Department of Critical Care Medicine, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China
Xiang Gao: Department of Critical Care Medicine, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China
He Miao: Department of Critical Care Medicine, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China
Xiaochun Ma: Department of Critical Care Medicine, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China
Renyu Ding: Corresponding author: Renyu Ding, Department of Critical Care Medicine, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China.; Department of Critical Care Medicine, The First Hospital of China Medical University, North Nanjing Street 155, Shenyang, Liaoning 110001, China

DOI: https://doi.org/10.1016/j.jointm.2021.03.002
Journal volume & issue: Vol. 1, no. 1
pp. 35 – 41

Abstract

Read online

Coagulopathy, characterized by a high D-dimer level, is a common pathological occurrence in coronavirus disease 2019 (COVID-19) and is associated with poor prognosis. Severe cases with COVID-19 is associated with a significantly higher risk of deep vein thrombosis and acute pulmonary embolism. Pulmonary intravascular coagulopathy is the characteristic coagulopathy in COVID-19. Unlike sepsis-induced coagulopathy and disseminated intravascular coagulation, which are manifestations of systemic coagulopathy, pulmonary intravascular coagulopathy is a manifestation of a local coagulation disorder in the lung. The progression from pulmonary intravascular coagulopathy to sepsis-induced coagulopathy or disseminated intravascular coagulation in the context of COVID-19 may indicate that the patient's coagulation dysfunction has progressed from local to systemic. Exploring the associated coagulation disease will aid in the understanding of the pathophysiological mechanisms underlying severe COVID-19.

Published in Journal of Intensive Medicine

ISSN: 2667-100X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid
Website: https://www.journals.elsevier.com/journal-of-intensive-medicine

About the journal

Abstract

Keywords