Clinical Parkinsonism & Related Disorders (Jan 2021)
Transcranial and muscular single-pulse magnetic stimulation is efficient on motor functional neurological disorders by the feedback of induced muscle contractions — A retrospective case series
Abstract
Objective: Motor functional neurological disorders (mFNDs) are improved by repetitive transcranial magnetic stimulation (rTMS), which is thought to involve cortical modulation. We examined the outcome of a rapid TMS procedure. Methods: Single-center retrospective case series including 41 consecutive patients suffering from mFNDs and receiving a combination of motor-evoked potentials (MEP), TMS and/or muscle stimulation. Results: MEP and additional TMS were administered in 35 patients, sometimes with rescue by muscle stimulation. Magnetic muscle stimulation was given in 6 patients, sometimes with rescue by TMS. Complete immediate recovery was obtained in 65.9 % of the 41 patients, but the outcome of mFNDs after one year was poor. Treatment by TMS (n = 19) or by muscle stimulation (n = 4) given alone were associated with 78.9 % and 75 % of complete immediate recovery, respectively. Conclusions: A rapid easy-to-perform TMS procedure obtained a high rate of immediate complete recovery in mFND. Clinical recovery was improved but was also obtained by direct magnetic stimulation of the paralyzed muscles. Significance: TMS-induced recovery of mFND may not involve cortical modulation but could rather occur through reinforcement of the suggestion. Magnetic-induced muscle twitches may facilitate the self-expectation of motor recovery and could unlock the motor symptoms of mFND.
