Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Xin Zhou; Yanghao Zhong; Olivia Molinar-Inglis; Maya T. Kunkel; Mingyuan Chen; Tengqian Sun; Jiao Zhang; John Y.-J. Shyy; JoAnn Trejo; Alexandra C. Newton; Jin Zhang

doi:10.1038/s41467-020-19937-w

Nature Communications (Nov 2020)

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Xin Zhou,
Yanghao Zhong,
Olivia Molinar-Inglis,
Maya T. Kunkel,
Mingyuan Chen,
Tengqian Sun,
Jiao Zhang,
John Y.-J. Shyy,
JoAnn Trejo,
Alexandra C. Newton,
Jin Zhang

Affiliations

Xin Zhou: Department of Pharmacology, University of California, San Diego
Yanghao Zhong: Department of Pharmacology, University of California, San Diego
Olivia Molinar-Inglis: Department of Pharmacology, University of California, San Diego
Maya T. Kunkel: Department of Pharmacology, University of California, San Diego
Mingyuan Chen: Department of Bioengineering, University of California, San Diego
Tengqian Sun: Department of Pharmacology, University of California, San Diego
Jiao Zhang: Division of Cardiology, Department of Medicine, University of California San Diego
John Y.-J. Shyy: Division of Cardiology, Department of Medicine, University of California San Diego
JoAnn Trejo: Department of Pharmacology, University of California, San Diego
Alexandra C. Newton: Department of Pharmacology, University of California, San Diego
Jin Zhang: Department of Pharmacology, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-020-19937-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinct in the nucleus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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