Nature Communications (Dec 2021)
A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
- Fan Yao,
- Yalan Deng,
- Yang Zhao,
- Ying Mei,
- Yilei Zhang,
- Xiaoguang Liu,
- Consuelo Martinez,
- Xiaohua Su,
- Roberto R. Rosato,
- Hongqi Teng,
- Qinglei Hang,
- Shannon Yap,
- Dahu Chen,
- Yumeng Wang,
- Mei-Ju May Chen,
- Mutian Zhang,
- Han Liang,
- Dong Xie,
- Xin Chen,
- Hao Zhu,
- Jenny C. Chang,
- M. James You,
- Yutong Sun,
- Boyi Gan,
- Li Ma
Affiliations
- Fan Yao
- Hubei Hongshan Laboratory, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University
- Yalan Deng
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yang Zhao
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Ying Mei
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yilei Zhang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xiaoguang Liu
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Consuelo Martinez
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xiaohua Su
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Roberto R. Rosato
- Houston Methodist Cancer Center, Houston Methodist Hospital
- Hongqi Teng
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Qinglei Hang
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Shannon Yap
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Dahu Chen
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Yumeng Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Mei-Ju May Chen
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Mutian Zhang
- Institute of Biosciences and Technology, Texas A&M University
- Han Liang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Dong Xie
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Xin Chen
- Department of Bioengineering and Therapeutic Sciences, University of California San Francisco
- Hao Zhu
- Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center
- Jenny C. Chang
- Houston Methodist Cancer Center, Houston Methodist Hospital
- M. James You
- Department of Hematopathology, The University of Texas MD Anderson Cancer Center
- Yutong Sun
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Boyi Gan
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Li Ma
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-27452-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Leukemia inhibitory factor receptor (LIFR) is frequently downregulated in liver cancer. Here the authors show that loss of LIFR promotes liver tumorigenesis and confers resistance to drug-induced ferroptosis through NF-κB-mediated upregulation of iron-sequestering cytokine LCN2.
