Risk Factors for Non-Adherence to Inhaled Corticosteroids in Preschool Children with Asthma
Louise Mandrup Bach,
Sune Rubak,
Adam Holm-Weber,
Julie Prahl,
Mette Hermansen,
Kirsten Skamstrup Hansen,
Bo Chawes
Affiliations
Louise Mandrup Bach
Department of Pediatric and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark
Sune Rubak
Danish Center of Pediatric Pulmonology and Allergology, Department of Pediatrics and Adolescents Medicine, Institute of Clinical Medicine, University Hospital of Aarhus, University of Aarhus, 8000 Aarhus, Denmark
Adam Holm-Weber
Department of Pediatric and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark
Julie Prahl
Department of Pediatric and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark
Mette Hermansen
Department of Pediatric and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark
Kirsten Skamstrup Hansen
Department of Pediatric and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark
Bo Chawes
Department of Pediatric and Adolescent Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark
Non-adherence to asthma controllers increases morbidity among school-aged children. This study aimed to determine non-adherence risk factors in preschool children with asthma. We investigated 172 children aAR:2.34 [1.10;4.98], p = 0.03), oral corticosteroids (aAR:2.45 [1.13;5.34], p = 0.026) or redeeming a short-acting b2-agonist prescription (aAR:2.91 [1.26;6.74], p = 0.015). Further, atopic comorbidity was associated with increased adherence (aAR:1.18 [1.01;1.37], p = 0.039), whereas having a first degree relative with asthma was associated with worse adherence (aAR:0.44 [0.23;0.84], p = 0.015). This study found poor adherence to ICS among three quarters of preschool children with asthma. Increasing adherence was associated with atopic comorbidity and loss of control events, whereas lower adherence was associated with atopic predisposition. These findings should be considered to improve adherence in preschool children with asthma.
