Nature Communications (May 2020)
Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection
- Drishti Kaul,
- Raveen Rathnasinghe,
- Marcela Ferres,
- Gene S. Tan,
- Aldo Barrera,
- Brett E. Pickett,
- Barbara A. Methe,
- Suman R. Das,
- Isolda Budnik,
- Rebecca A. Halpin,
- David Wentworth,
- Mirco Schmolke,
- Ignacio Mena,
- Randy A. Albrecht,
- Indresh Singh,
- Karen E. Nelson,
- Adolfo García-Sastre,
- Chris L. Dupont,
- Rafael A. Medina
Affiliations
- Drishti Kaul
- J. Craig Venter Institute
- Raveen Rathnasinghe
- Departmento de Enfermedades Infecciosas e Inmunología Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile
- Marcela Ferres
- Departmento de Enfermedades Infecciosas e Inmunología Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile
- Gene S. Tan
- J. Craig Venter Institute
- Aldo Barrera
- Departmento de Enfermedades Infecciosas e Inmunología Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile
- Brett E. Pickett
- J. Craig Venter Institute
- Barbara A. Methe
- J. Craig Venter Institute
- Suman R. Das
- J. Craig Venter Institute
- Isolda Budnik
- Departmento de Enfermedades Infecciosas e Inmunología Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile
- Rebecca A. Halpin
- J. Craig Venter Institute
- David Wentworth
- J. Craig Venter Institute
- Mirco Schmolke
- Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
- Ignacio Mena
- Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
- Randy A. Albrecht
- Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
- Indresh Singh
- J. Craig Venter Institute
- Karen E. Nelson
- J. Craig Venter Institute
- Adolfo García-Sastre
- Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
- Chris L. Dupont
- J. Craig Venter Institute
- Rafael A. Medina
- Departmento de Enfermedades Infecciosas e Inmunología Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile
- DOI
- https://doi.org/10.1038/s41467-020-16429-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Influenza A virus (IAV) infection can be exacerbated by bacterial co-infections but the effect of IAV on the upper respiratory tract (URT) microbiome remains unclear. Here, the authors compare the dynamics of the UTR microbiome in IAV-infected ferrets and humans, finding similar trends at the ecosystem and individual taxon level in both hosts.
