Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma

• Lisa C. Holthof,
• Hilma J. van der Horst,
• Susan E. van Hal-van Veen,
• Ruud W.J. Ruiter,
• Fengzhi Li,
• Marijke Buijze,
• Morten N. Andersen,
• Huipin Yuan,
• Joost de Bruijn,
• Niels W.C.J. van de Donk,
• Henk M. Lokhorst,
• Sonja Zweegman,
• Richard W.J. Groen,
• Tuna Mutis

Affiliations

Lisa C. Holthof

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Hilma J. van der Horst

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Susan E. van Hal-van Veen

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Ruud W.J. Ruiter

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Fengzhi Li

Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, New York, NJ USA

Marijke Buijze

Department of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Morten N. Andersen

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark;Department of Biomedicine, Aarhus University, Aarhus, Denmark;Department of Hematology, Aarhus University Hospital, Aarhus, Denmark

Huipin Yuan

Kuros Biosciences BV, Bilthoven, the Netherlands

Joost de Bruijn

Kuros Biosciences BV, Bilthoven, the Netherlands;The School of Engineering and Materials Science, Queen Mary University of London, London, UK

Niels W.C.J. van de Donk

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Henk M. Lokhorst

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Sonja Zweegman

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Richard W.J. Groen

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands

Tuna Mutis

Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands