Nature Communications (May 2019)
Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
- George B. Saffouri,
- Robin R. Shields-Cutler,
- Jun Chen,
- Yi Yang,
- Heather R. Lekatz,
- Vanessa L. Hale,
- Janice M. Cho,
- Eric J. Battaglioli,
- Yogesh Bhattarai,
- Kevin J. Thompson,
- Krishna K. Kalari,
- Gaurav Behera,
- Jonathan C. Berry,
- Stephanie A. Peters,
- Robin Patel,
- Audrey N. Schuetz,
- Jeremiah J. Faith,
- Michael Camilleri,
- Justin L. Sonnenburg,
- Gianrico Farrugia,
- Jonathan R. Swann,
- Madhusudan Grover,
- Dan Knights,
- Purna C. Kashyap
Affiliations
- George B. Saffouri
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Robin R. Shields-Cutler
- BioTechnology Institute, College of Biological Sciences, University of Minnesota
- Jun Chen
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic
- Yi Yang
- Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College
- Heather R. Lekatz
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Vanessa L. Hale
- Department of Veterinary Preventive Medicine, The Ohio State University
- Janice M. Cho
- Division of Internal Medicine, Mayo Clinic
- Eric J. Battaglioli
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Yogesh Bhattarai
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Kevin J. Thompson
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic
- Krishna K. Kalari
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic
- Gaurav Behera
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Jonathan C. Berry
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Stephanie A. Peters
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Robin Patel
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Audrey N. Schuetz
- Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Jeremiah J. Faith
- Department of Genetics and Genomic Sciences, Medicine, and Clinical Immunology, Icahn School of Medicine at Mount Sinai
- Michael Camilleri
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Justin L. Sonnenburg
- Department of Microbiology and Immunology, Stanford University
- Gianrico Farrugia
- Division of Gastroenterology, Mayo Clinic
- Jonathan R. Swann
- Computational and Systems Medicine Section of the Department of Surgery and Cancer, Imperial College
- Madhusudan Grover
- Division of Gastroenterology and Hepatology, Mayo Clinic
- Dan Knights
- BioTechnology Institute, College of Biological Sciences, University of Minnesota
- Purna C. Kashyap
- Division of Gastroenterology and Hepatology, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-019-09964-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Small intestinal bacterial overgrowth (SIBO) has been associated with functional gastrointestinal disorders. Here, the authors show that SIBO may be a result of dietary preferences, and patient symptoms correlate with changes in small intestinal microbial composition but not with SIBO.
